IGF-1 LR3 1MG | Purity 99.51%

99%+ Purity Purity 99.51% / Avg. mass 1.11 mg Each vial contains 1 mg of highly pure IGF-1 LR3.

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic 83–amino acid analog of human IGF-1, engineered with an arginine substitution at position 3 and a 13–amino acid N-terminal extension. These modifications dramatically reduce binding affinity to IGF-binding proteins (IGFBPs) — the regulatory proteins that normally sequester and deactivate circulating IGF-1. The result is a significantly extended biological half-life and greater bioavailability compared to native IGF-1.

With reduced IGFBP interference, IGF-1 LR3 maintains prolonged activation of the IGF-1 receptor (IGF-1R) and its downstream PI3K/Akt and MAPK/ERK signaling cascades — pathways central to protein synthesis, cellular proliferation, and anti-apoptotic signaling. In preclinical research, this translates to enhanced nitrogen retention in skeletal muscle, increased satellite cell activation, hyperplasia (new cell formation rather than simple hypertrophy), and improved glucose uptake in peripheral tissues.

This extended-activity profile makes IGF-1 LR3 a powerful research tool for investigating growth factor signaling, muscle biology, and metabolic regulation beyond what native IGF-1 protocols can achieve.